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Smart Anti-Burglary System
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The smart anti-burglary system does not require electricity supply and works on battery.
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A young Iranian inventor, Amir Rezaei, has invented a smart anti-burglary system for public places, including banks.
ÒThe system consists of two locks. When a person enters the public place in question, the first lock is automatically activated. After this, the system identifies the person. If he/she is authorized to enter, it opens the door and if not, first the second lock is activated, then the siren goes off and closed-circuit camera films the burglar and concurrently contacts some 20 people who have been specified beforehand,Ó Rezaei told Fars News Agency.
The system does not require electricity supply and works on battery. Another feature of this system is that the burglar cannot tell if the lock is smart or not.
ÒThe lock is activated before the burglarÕs entry and the system starts filming the burglar. This is while previous anti-burglary systems did this after the burglar entered the premises. The second lock, which does not allow the entry of burglar, distinguishes this system from other anti-burglary systems,Ó he said.
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Fluorescent Nanoparticles to Help Track Drug Intake
Researchers in the Department of Physics and Astronomy at the University of Leicester have developed a new synthesis method, which has led them to the discovery of fluorescent silicon nanoparticles and may ultimately help track the intake of drugs by the bodyÕs cells.
Dr Klaus von Haeften explained that a key advantage of the new method is the independent control of the nanoparticlesÕ size and their surface properties, ScienceDaily wrote.
The method is extremely versatile and produces the fluorescent suspensions in one go. The findings may revolutionize the performance of electronic chips while satisfying the increasing demand for higher integration densities.
The nanoparticles contain just a few hundred silicon atoms and their fluorescence was discovered after mixing them with water. This resulted in stability in fluorescence intensity over more than a three-month period.
An interdisciplinary research project with the Department of Chemistry, led by Professor Chris Binns and Dr Glenn Burley, also incorporates this new method of synthesis. They are aiming to link nanoparticles to drugs involved in the diagnosis and treatment of cancer.
Professor of Nanoscience in the Department of Physics and Astonomy, Chris Binns, said nanotechnology, that is, the use of structures whose dimensions are on the nanometer scale, to build new materials and devices, appears to hold the key to future developments in a wide range of technologies, including materials, science, information technology and healthcare.
Dr von Haeften added that the approach developed in Leicester could be a key step toward the production of a variety of biomedical sensors that could help track the intake of drugs by cells.
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2nd Testicular Cancer Gene Identified
A second gene linked to inherited testicular germ-cell cancer has been identified by scientists at the US National Institutes of Health.
According to HealthDay News, this study contributes to understanding why testicular germ-cell cancer appears to run in families.
Dr. Raynard Kington, acting NIH director, said in an agency news release, ÒThe findings may also lead to new ways to identify men at high risk, as well as more effective ways to prevent and treat testicular germ-call cancer.Ó
The US National Cancer Institute estimates that 8,400 men will be diagnosed with testicular cancer this year, and that about 90 percent of the cases will be germ-cell cancers.
For the study, the scientists analyzed DNA from 95 familial testicular cancer patients and found seven different mutations in a gene called PDE11A. Healthy men did not have the mutations.
ÒThe mutations donÕt cause cancer directly, but instead appear to increase an individualÕs susceptibility to developing a tumor,Ó the studyÕs senior author, Dr. Constantine Stratakis, chief of the endocrinology and genetics section at the National Institute of Child Health and Human Development, said in the news release.
The PDE11A gene is located in a key biochemical pathway in testicular germ-cell cancer, the cyclic AMP pathway, which regulates how cells respond to such signals as hormones. Drugs that affect the AMP pathway are widely available and, in theory, may help slow progression of testicular cancer.
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Schizophrenia, Manic Depression Linked
Scientists in three studies have identified similar genetic causes behind both schizophrenia and manic depression in a discovery that could lead to new treatments for millions with the illnesses.
The new research has uncovered a common genetic basis for the two mental illnesses, which doctors had previously considered separate, Telegraph reported.
The discovery was made by three separate international teams who investigated the genetic basis of schizophrenia by pooling information about 15,000 patients and nearly 50,000 healthy subjects to conclude that thousands of tiny genetic mutations--known as single nucleotide polymorphisms (SNPs)--are responsible for about one-third of the risk of developing the illness.
The studies also found that the same genetic variations in SNPs were linked with manic depression, despite the two conditions being treated as if they were unrelated.
Although the breakthrough does not bring scientists closer to a cure for the illnesses, it allows researchers to narrow the hunt for further information about why they develop and how they can be contained.
Major Breakthrough
Michael OÕDonovan, professor of psychiatric genetics at the Medical Research CouncilÕs neurogenetics center in Cardiff, said, ÒThis is a pretty major breakthrough for us because before today you could count on the thumb of one hand the number of common [genetic] variants that have been reliably identified for schizophrenia.
ÒSome of us were surprised to find that not only did these genes contribute to schizophrenia but they also contribute to bipolar disorder. So, that really suggests that the two disorders are not really as distinct as we thought in psychiatry.Ó
Thomas Insel, director of the US National Institute for Mental Health in Bethesda, Maryland, which part-funded the studies, said: ÒIf some of the same genetic risks underlie schizophrenia and bipolar disorder, perhaps these disorders originate from some common vulnerability in brain development. Of course, the big question then is how some people develop schizophrenia and others develop bipolar disorder.Ó
The three studies have been possible because of technical advances in the analysis of the genomes of patients, enabling scientists to examine vast amounts of DNA to draw more accurate conclusions than in the past.
Schizophrenia affects one in 100 people at some time in their life. It is a chronic, long-term illness resulting in persistent delusions and hallucinations and is estimated to cost the taxpayer about £2bn a year in care and treatment.
Bipolar disorder or manic depression is marked by unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. It can exaggerate the Ôups and downsÕ experienced by everyone, increasing the risk of suicide.
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Intense Heat Killed Would-Be Galaxies
Our Milky Way galaxy only survived because it was already immersed in a large clump of dark matter that trapped gases inside it, scientists found.
The researchers said that the early Milky Way held on to the raw gaseous material from which further stars would be made, Physorg reported.
This material would otherwise have been evaporated by the high temperatures generated by the ÔignitionÕ of the Universe about half-a-billion years after the Big Bang.
Tiny galaxies, inside small clumps of dark matter, were blasted away by the heat which reached approximate temperatures of between 20,000 and 100,000 degrees centigrade.
Dark matter is thought to make up 85 percent of the UniverseÕs mass and is believed to be one of the building blocks of galaxy formation.
Astronomers have found a few dozen small satellites around the Milky Way, but the simulations revealed that hundreds of thousands of small clumps of dark matter should be orbiting our galaxy.
The scientists said the heat from the early stars and black holes rendered this dark matter barren and unable to support the development of satellite star systems.
Joint lead investigator Professor Carlos Frenk, who is also director of the Institute for Computational Cosmology, at Durham University, said, ÒWe can demonstrate that it was almost impossible for these potential galaxies to survive the extreme heat generated by the first stars and black holes.
ÒThe heat evaporated gas from the small dark matter clumps, rendering them barren. Only a few dozen frontrunners, which had a head-start on making stars before the Universe ignited, managed to survive.Ó
By providing a natural explanation for the origin of galaxies, the simulations support the view that cold dark matter is the best candidate for the mysterious material believed to make up the majority of our Universe, the scientists added.
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X-Rays for AlzheimerÕs
Researchers at the US Department of EnergyÕs Brookhaven National Laboratory have demonstrated a new, highly detailed x-ray imaging technique that could be developed into a method for early diagnosis of AlzheimerÕs disease.
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Laser Weapon Dazzles Not Blinds
The Pentagon is working on a laser dazzler that will force drivers to stop without harming their eyes.
When a vehicle approaches a checkpoint at speed, ignoring warning signs to slow down, troops do not know whether the driver is simply careless or a suicide bomber. They need a clear and harmless way of forcing drivers to stop, NewScientist reported.
Green laser dazzlers designed to temporarily blind drivers were sent to US forces in Iraq and Afghanistan for just this purpose. But at short range they can damage the eye, and a number of US troops and civilians have ended up in hospital with eye injuries after Òfriendly fireÓ incidents.
Now the US Department of DefenseÕs Joint Non-Lethal Weapons Directorate in Quantico, Virginia, is developing a pulsed laser designed to prevent eye damage. Its wavelength means a portion of the light is absorbed by the vehicle windscreen, vaporizing the outer layer of the glass and producing a plasma. This absorbs the rest of the pulse and reemits the energy as a brilliant white light that is dazzling but harmless.
Because the light is emitted from the windscreen, the effect on the driverÕs eyes should be the same regardless of the vehicleÕs distance from the laser.
New Therapy May Work Against Leukemia
A new targeted therapy shows promise in treating acute myeloid leukemia, a highly treatment-resistant blood cancer, according to a new study.
Researchers created an antibody (7G3) that recognizes and binds to a molecule called CD123, which is expressed at high levels on leukemia stem cells (LSCs), but not on normal blood cells, HealthDay News reported.
LSCs are cells that can cause acute myeloid leukemia (AML) and are critical for its long-term growth.
When AML-LSCs from human patients were transplanted into mice, those treated with 7G3 survived longer than mice that didnÕt receive the antibody. The researchers found that 7G3 blocked a signaling pathway in tumor cells, impaired migration of AML-LSCs to bone marrow and activated the immune system to destroy AML-LSCs.
The findings hold promise for future cancer treatments, according to the study authors.
ÒThe recent characterization of defined populations of cancer stem cells in a range of human malignancies, as well as their relative resistance to conventional chemotherapy and radiotherapy, supports the broad applicability of our approach and provides rationale for the progression of AML-LSC-targeted therapeutics from preclinical evaluation to clinical trials,Ó wrote Richard Lock, an associate professor at the ChildrenÕs Cancer Institute Australia and the University of New South Wales, in a news release.
Pregnancies Affect Liver Malignancy
Risk for hepatocellular carcinoma, a primary malignancy of the liver, was statistically significantly higher among women with hepatitis B virus (HBV) infection than among women without the virus, according to a new study.
Because hepatocellular carcinoma mostly occurs in men, few women have been included in long-term studies of the association between HBV infection and this carcinoma, ScienceDaily reported.
In this study, Chien-Jen Chen, Sc.D., of the Genomics Research Center in Taipei, Taiwan, and colleagues used a nationwide cohort of more than 1.5 million pregnant Taiwanese women tested from 1983 to 2000 to study relationships of HBV infection and parity with hepatocellular risk.
The researchers found that risk for hepatocellular carcinoma during follow-up was statistically significantly higher among pregnant women who had chronic, active, or persistent HBV infections (and even in those who had seroclearance for hepatitis B surface antigen during follow-up) than among women who were not carriers of hepatitis B surface antigen at study entry.
The more children a woman had, the lower her risk appeared to be. This inverse relationship between parity and the risk of hepatocellular carcinoma was statistically significant.
ÒUnderlying biological mechanisms responsible for thisÉmerit further investigation,Ó the authors write.
Golfing for the Disabled
The Paramobile from Parabasetec (Bodensee, Germany) is a new type of powered wheelchair specifically designed for golfers.
The wheelchair is also suitable for hunting, archery and any other activity that require standing but not necessarily walking, Ideaconnection reported.
This machine seems to be an item that golf course operators should have on hand for disabled players.
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