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Red blood cells are scythe shaped in sickle cell anemia.
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Scientists believe they have uncovered why people with a gene for a blood disorder are immune to malaria, BBC News website reported.
It is known that people with a single gene for sickle cell anemia, but not the full-blown condition, are somewhat resistant to the malaria parasite.
Some say the distorted red blood cells caused by the gene are broken down quicker than normal by the body so malaria has no home in which to thrive.
Now a Wellcome Trust team suggests the immune system also plays a big role.
By studying more than 1,000 children living on the coast of Kenya, where malaria is rife, they found many with the sickle cell trait developed increasing protection against malaria as they aged.
Between the ages of two and 10, immunity to the disease rose rapidly.
The protection against malaria was around 20% in the first two years of life compared with over 50% by the age of 10, the researchers report in the journal PLoS Medicine.
However, protection is not 100%, so people with the trait still need to be aware of the risks of malaria, they stressed.
Lead researcher Dr Tom Williams said, “It has been known for some time that sickle cell trait offers this protection, but the accelerated level of immunity in the first years of life has not been revealed before.“
He said there were several possible reasons why this happened, but that further research was needed to know for sure.
One explanation might be that although the bulk of blood cells carrying malaria are destroyed quickly, a few may escape destruction - but not enough to cause malaria symptoms.
This would allow the immune system time to gradually build up an effective defense against malaria, he suggested.